Ten most populous counties in Missouri, 1990 Projected 2020 1990 Rank County Population 1 St. Louis 993,529 2 Jackson 633,232 3 St. Louis City 396,685 4 St. Charles 212,907 5 Greene 207,949 6 Jefferson 171,380 7 Clay 153,411 8 Boone 112,379 9 Jasper 90,465 10 Buchanan 83,083 SCENARIO L 2020 Rank County Population 1 St. Louis 973,585 2 Jackson 626,649 3 St. Charles 391,340 4 St. Louis City 270,760 5 Greene 248,222 6 Jefferson 234,351 7 Clay 188,879 8 Boone 156,670 9 Franklin 105,253 10 Jasper 98,839 SCENARIO R 2020 Rank County Population 1 St. Louis 983,990 2 Jackson 600,237 3 St. Charles 383,844 4 Greene 259,778 5 Jefferson 254,255 6 St. Louis City 223,261 7 Clay 205,792 8 Boone 166,393 9 Franklin 111,248 10 Cass 102,654 SCENARIO Z 2020 Rank County Population 1 St. Louis 1,075,161 2 Jackson 725,595 3 St. Louis City 475,033 4 St. Charles 270,977 5 Greene 230,699 6 Jefferson 206,799 7 Clay 170,716 8 Boone 140,187 9 Jasper 103,516 10 Franklin 95,562 Source: USDC, Bureau of the Census and the Missouri Office of Administration